Post-Doc Positions Supported by Marie Sklodowska-Curie Actions

15 EU Marie Sklodowska-Curie PhD Positions across Europe

Organisation:  Biomedical Center – LMU Munich (Germany)
Application deadline:  08/08/2016

We are seeking 15 talented early-stage researchers (ESRs). Each ESR will join the research lab of a ChroMe network member and develop his/her own research project at the intersection of chromatin and metabolism. ESRs will enroll in local PhD programs and travel to attend events organized by ChroMe to train research and complementary skills. Research visits to other network members are planned and further encouraged. Our research positions are at the interface of molecular biology, physiology and bioinformatics. The network is thus suited to students of these disciplines, but we encourage also applicants from (bio-)chemistry, nutritional sciences, physics or engineering backgrounds.
Description
The available projects
No.1: Structure/function analysis of essential sugar-regulated transcription factors. (Ladurner, Munich)
No.2: Cell type specific sugar mediated gene transcription. (Margulies, Munich)
No.3: Effects of targeting key metabolic enzymes on post-translational protein modifications. (Imhof, Munich)
No.4: The biological role of metabolite binding by macroH2A histones. (Buschbeck, Barcelona)
No.5: The influence of chromatin regulators on metabolic activity and hematologic diseases. (Buschbeck, Barcelona)
No.6: Genomic and metabolomic fingerprint of skeletal muscle insulin resistance and the adaptive response to exercise in Type 2 diabetic patients. (Zierath, Stockholm)
No.7: Metabolism of gut microbiota regulates histone modifications in host tissues. (Yanes, Tarragona)
No.8: Determine Glucose sensing mechanisms through the mammalian transcription factor ChREBP. (Postic, Paris)
No.9: Pancreatic beta-cell Polycomb deficiency induces cellular dedifferentiation and diabetes. (Pospisilik, Freiburg)
No.10: Epigenetic regulators for diabetes therapeutics. (Ferrer, London)
No.11: Hypothalamic class IIa histone deacetylases regulate energy and glucose metabolism. (Tschoep, Munich)
No.12: Integrative analysis of functional isoforms-resolved transcriptomics, metabolomics and epigenomic changes during developmental courses. (Conesa, Valencia)
No.13: The microbiome and metabolome in aging rodents. (Mellor, Oxford)
No.14: Metabolic regulation of and by epigenetic targets and new therapeutic options. (Dreker, Munich)
No.15: The impact of mitochondrial dynamics in metabolic signalling networks. (Canto, Lausanne)

Nr of positions available : 15
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34099931

19 PhD positions for joint research on novel antimicrobials

Organisation:  ALERT-COFUND PhD Program (The Netherlands)
Application deadline:  09/08/2016

The ALERT-COFUND international PhD program offers 19 fellowships for a joint program on antimicrobial research. The ALERT program aims to empower fellows to become the next generation of antimicrobial experts, who take a leading position in tackling the challenge of emerging multidrug resistant bacteria. The program aims to develop novel tailor-made antimicrobials and delivery strategies, from synthesis towards clinical applications. Under the supervision of top scientists, 19 PhDs will conduct research within four task areas: chemical synthesis, biotechnological synthesis, nanotechnology approaches and in vivo testing.

The most talented and motivated students will be selected for a 4-year advanced multidisciplinary research training with specialist training through cutting-edge research projects, specialist advanced courses and training schools. In addition, fellows will have the opportunity to go abroad on international secondments at leading places in academia and industry.
Description
Joint research program on novel tailor-made antimicrobials and delivery strategies
The current overuse of antibiotics is leading to the emergence of multidrug resistant (MDR) bacteria. These MDR pathogens continue to evolve at a terrifying rate and confer resistance to most or all presently available antibacterial treatments. Antimicrobial resistance is an eminent global problem that calls for an integrated approach that surpasses disciplines, sectors and borders.

The ALERT program aims to develop novel tailor-made antimicrobials and delivery strategies, from synthesis towards clinical applications. Under the supervision of top scientists in different fields and sectors related to antimicrobial research, 19 PhDs will conduct research within four main areas:

• Chemical synthesis of antimicrobials (5 PhD’s)
To investigate methods that drastically shorten the time for identifying and preparing novel antimicrobial molecules, using innovative chemical synthesis approaches.

• Biotechnological production of antimicrobials (4 PhD’s)
To enable the development of new antimicrobials employing biotechnological tools, taking into consideration the design and construction of novel drug molecules.

• Nanotechnology approaches to create antimicrobials (5 PhD’s) To create new antimicrobials that can treat infections in the body locally by using nanotechnology approaches.

• In vivo testing (5 PhD’s)
To test the most promising antimicrobial drug candidates in animal models.

Nr of positions available : 19
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34092259

5 PhD Studentships in Chemical Biology – Molecular Tools for Nucleic Acid Manipulation for Biological Intervention (MMBio)

Organisation:  University of Cambridge – Chemical Biology (UK)
Application deadline:  10/08/2016
MMBio is a Marie Curie Initial Training Network set up to provide young researchers with hands-on research experience and formal training in the classically separate disciplines of Chemistry and Biology.
Description
The objective of MMBio is to develop enabling technologies to ultimately cure cellular disease phenotypes by employing molecular, chemical and biological approaches to interfere with gene expression precisely and selectively. MMBio will focus on unconventional new therapeutic approaches, namely “genetic” drugs that are typically based on oligonucleotides (ONs). Reaching these objectives will include multiple skills of Chemical Biology: synthetic chemistry, quantitative mechanistic analysis of recognition and catalysis, high-throughput screening in microfluidic systems, work with nanoparticles and directed evolution of enzymes. See the research interests of the individual participating groups for further details – http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio/mmbiofront#partners

Nr of positions available : 15

For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34094398

PhD position in Chromatin and Epigenetics, Barcelona (Ref. 2016/50)

Organisation:  IMPPC (Spain)
Application deadline:  10/08/2016
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How do chromatin alterations contribute to cell fate transitions? How does the environment influence these processes? And how does the metabolic state of a cell impact on its chromatin structure and its epigenetic memory? These are questions we address in the lab. Studying stem cells and cancer we focus on fundamental aspects of epigenetic regulation and on the question whether we can translate this knowledge into diagnostic and therapeutic tools for the management of diseases such as leukemia and myelodysplastic syndrome.
Several PhD positions are available in the Chromatin, Metabolism and Cell Fate group at the IJC. We will discuss and shape the project together with you.
Description
Depending of the project you will combine biochemistry, genetic manipulation of cell cultures and epigenomics. As model system for cell differentiation you will use embryonic stem cells, myoblasts or hematopoietic cells. Key findings will be validated in vivo. For the study of cancer you will combine established cell lines, primary cultures and patient samples. You will present and discuss your results in team, group and institute meetings and enroll in a PhD program

Nr of positions available : 1
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34101479

5 PhD Studentships in Protein Engineering, Directed Evolution, Bioinformatics and Enzyme Mechanism

Organisation:  University of Cambridge (UK) – Chemical Biology
Application deadline:  10/08/2016
ES-Cat is a Marie Curie Initial Training Network set up to provide young researchers with hands-on research experience and formal training in directed evolution, protein engineering, bioinformatics, chemical biology and mechanistic enzymology.
Description
The objective of ES-Cat is to use explore new strategies for the creation of novel enzymes and biocatalysts. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how enzyme mechanisms can be manipulated.
This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets.
It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy.

Nr of positions available : 15

For more information: http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34096117

Early Stage Researcher in data mining

Organisation:  Ariana Pharmaceuticals (France)
Application deadline:  26/08/2016
Data analytics using proprietary software for biomarker and clinical studies
Description
Working in a multidisciplinary environment, the successful candidate will be using advanced data analytics techniques including our KEM® data mining software to analyze data from biomarker and clinical studies.

Candidate’s activities will include contributing to the design of study plans, developing and applying new, domain specific data mining and statistical methods, writing up study reports as well as presenting the results and suggesting interpretations.

Nr of positions available : 1
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34100433

OPEN PHD POSITION ON PLANT PHENOTYPING

Organisation:  Photon Systems Instruments (Czech Republic)
Application deadline:  30/08/2016
R&D department of Photon Systems Instruments (PSI) is looking for a motivated and skilled candidate for a PhD position on plant phenotyping in frame of EU international training network (ITN) project SE2B. PSI is internationally recognized and innovation oriented SME company offering application-oriented research opportunity in field of automated plant phenotyping.
The PhD project will deal with “Phenotyping methods for non-invasive monitoring of plant fitness and growth performance in controlled and greenhouse environment“.
The successful candidate will focus on the establishment, validation, data analysis and further development of non-invasive techniques for monitoring plant fitness and growth performance by using unique greenhouse and controlled environment -based automated multi-sensoric phenotyping platforms.
Description
Background
Plant phenotyping refers to a quantitative characterisation of the plant’s anatomical, ontogenetical, physiological and biochemical properties at regular time intervals, non-destructively and objectively. In past years plant phenotyping became increasingly automated by the development of novel imaging technologies and image analysis pipelines that allow for a characterization of plant traits in high-throughput and high-precission. The field of image-based phenotyping has broadened from the initial characterization of single-plant traits in controlled conditions towards greenhouse and field applications and multi-dimensional dynamic phenotyping of morphological, physiological and biochemical traits.
In several past years PSI has developped and manufactured range of automated plant phenotyping systems for controlled and greenhouse conditions. The PlantScreen Phenotyping Systems are designed for in-depth phenotyping of small up to large-scale plants ranging from Arabidopsis to crop species by means of RGB, kinetic chlorophyll fluorescence, thermal infrared, 3D laser scanning and hyperspectral imaging systems.
The project aims to investigate and validate current technological improvements and develop, optimize and standardize the phenotyping protocols for the hyperspectral imaging sensor, chlorophyll fluorescence sensor and projectionof the acquired data on 3D structural models. The insights obtained will be translated into actual applications in basic research and in agriculture research. The succesful candidate will work in a mixed team of company and university employees and will be involved in close cooperative partnerships between PSI and internationally renowed groups involved in automated high-throughput phenotyping.
The 3-year project is funded by Marie Curie Actions (Innovative Training Network).
Requirements
We are looking for an excellent student who is a result-driven team player with good communication skills and good proficiency in English (both oral and written).

Specific requirements:
• A university degree at MSc level in plant sciences or biotechnology
• Strong scientific interest in phenotyping and automated image-analysis
• Profound knowledge of plant physiology is of advantage
• Experience with photosynthesis research is of advantage (gas exchange, chlorophyll fluorescence)
• Knowledge of basic statistical methods and large data-set analysis is recommended
• Capability to operate in dynamic environment between universities and private companies

Nr of positions available : 1
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34102233

PhD at LDC ” Small-molecule stabilizers of the 14-3-3″

Organisation:  Lead Discovery Center GmbH (Germany)
Application deadline:  31/08/2016
Modulation of Protein-Protein Interactions (PPIs) with small-molecules is one of the most promising and challenging areas in Chemical Biology and Drug Discovery. Whereas inhibition of PPIs is meanwhile a well-documented and successful strategy, the opposite approach of small-molecule stabilization of PPIs has not been followed systematically. The adapter protein 14-3-3 acts as a ‘hub’ by interacting with several hundred partner proteins in human cells. These 14-3-3 PPIs are implicated in a number of diseases ranging from cancer and neurodegeneration to inflammation and metabolic syndromes. In the Innovative Training Network TASPPI (Targeted Stabilization of Protein-Protein Interactions) we aim in a consortium of 5 universities (Dundee, Eindhoven, Leeds, Lille, Prague, Siena), 3 pharma companies (AstraZeneca, GSK, UCB), and 2 SMEs (LDC, Taros) to identify and optimize small-molecule 14-3-3 PPI stabilizers as novel tools for basic research and starting points for drug development.
Description
The position described here is to be filled at Lead Discovery Center GmbH (LDC), Dortmund, Germany, while the applicant will be enrolled in a PhD program at the University Eindhoven, The Netherlands. The successful candidate (Early Stage Researcher, ESR) will work together with 12 other PhDs within TASPPI and will be included in a network-wide training and secondment program. Tasks include: Implement and perform HTS for the projects of the TASPPI consortium and identify validated hits that will be further optimized and profiled by use of Medicinal Chemistry and in vitro Pharmacology (evaluation of ADMET parameters). The successful candidate will apply a broad spectrum of assay technologies as HTRF, AlphaSreen, Surface Plasmon Resonance etc. and will be intensively trained in the field of drug discovery. The successful candidate will be additionally trained in project management at the interface of academic and pharmaceutical research, in patent searches and protection of intellectual property.

Nr of positions available : 1
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34098545

EMBL Interdisciplinary Postdocs

Organisation:  EMBL (Germany)
Application deadline:  05/09/2016
The EIPOD programme underlines EMBL’s strong commitment to promoting interdisciplinary research. The institution has a long-standing tradition of scientific excellence that builds on highly interactive research between the group leaders of different research units. EIPOD projects capitalise on synergies emerging at the borders of overlapping yet separate scientific fields, and involve transferring techniques to a novel context. The programme is open to all nationalities and offers about 20 positions annually.
Description
The call for applications for the 2016 EMBL Interdisciplinary Postdocs Fellowship (EIPOD) is now open until September 5th. The fellowships are funded by EMBL and a grant from Marie Skłodowska-Curie actions from the EU and provide young scientist with full funding for a three year position. Applicants are invited to propose an interdisciplinary project according to their scientific interest. Each project should involve two EMBL groups. External partners from academia or industry are welcome. Successful candidates will pursue interdisciplinary projects, transferring techniques to a new context or connecting scientific fields that are usually separate, across at least two labs at the five EMBL sites.

Nr of positions available : 20
For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34098566
 

Marie Skłodowska-Curie Individual Fellowship (Microbiology – Cell biology)

Organisation:  University of Roehampton (UK)
Application deadline:  07/09/2016

We are seeking a postdoctoral researcher to apply for a Marie Skłodowska-Curie Individual Fellowship to work on MRSA pathogenesis.
Description
Our objective is to dissect the interaction of Methicillin-Resistant Staphylococcus aureus (MRSA) with mammalian host cells. We have recently discovered that the depletion of a human membrane protein called TMEM59 results in the reduced intracellular replication of MRSA (EMBO J, 2013. 32(4):566-82). The candidate will perform a range of genomic, proteomic and metabolic profiling studies to find previously unknown factors required for the intracellular survival of MRSA. This could lead to the identification of novel host-targeted therapeutics against MRSA, which may circumvent the problem of antibiotic resistance.

The successful applicant will join the Health Sciences Research Centre (HSRC) at the University of Roehampton, the most research-intensive modern university within the UK (REF2014). The HSRC represents a multidisciplinary team with research interests on different aspects of human disease, ranging from neurological disorders, to bacterial infections or metabolic disorders. 84% of our research output is rated as internationally excellent and world leading in terms of originality, significance and rigour (REF2014).

The HSRC has well-equipped laboratories including an ultra-high performance liquid chromatography triple quadrupole mass spectrometer (UPLC-(TQ)-MS), clinical and microscopy analysers, molecular biology equipment, and cell and tissue culture facilities. Our excellent research facilities make the HSRC a stimulating environment for postdoctoral researchers.

Nr of positions available : 1

For more information:http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34084398

3 PhD positions PRONKJEWAIL – Iatrogenic influence on the microbiome

Organisation:  University Medical Center Groningen (The Netherlands)
Application deadline:  30/09/2016
Microbes in Health and Disease program at the UMCG, the Netherlands offers 16 PhD positions within the project PRONKJEWAIL (H2020/MSCA COFUND). Research training builds on 4 Pillars: 1) Vaccines and primary prevention, 2) Personalized detection and infection prevention, 3) Iatrogenic influence on the microbiome, 4) Personalized therapy/stewardship.
Applicants must hold a master’s degree or equivalent, be in the first 4 years of their career and not yet have been awarded a doctoral degree. Applicants must not have been resident at the Netherlands for more than 12 months in the past 3 years.
Please email your application to pronkjewail@umcg.nl. The application must be a single pdf file including motivation letter, CV, copies of Master’s degree or equivalent, list of grades, English proficiency certificate (TOEFL > 6.5, IELTS > 92 or equivalent) and 2 letters of recommendation. In the subject of the email indicate the selected position. In the file name include YOUR_NAME_ESR_number.
Description
Iatrogenic influence on the microbiome

ESR 3.1 The influence of the presence of antibiotics, chlorine, disinfectants and heavy metals in environmental water streams on the gut microbiome

The goal of this project is to study the influence of the presence of antibiotic, chlorine, disinfectants and heavy metals in environmental water streams on the gut microbiome, possibly leading to an increased presence of antibiotic resistant bacteria (ARB) in the gut. The results will be used to support prevention and improve diagnostics of ARB in patients. The PhD student will analyze the effect of colonization with community-acquired ARB. Specific requirements: background in water research, veterinary research, medical microbiology or molecular biology; knowledge of next generation sequencing and/or bioinformatics is beneficial.

ESR 3.2 The effect of hospitalization and drug use on the composition of the oral and fecal microbiome

Hospitalization and drug use have an effect on the normal functioning of the body and its relationship with microbes. Infectious complications in patients may be associated with a dysbiosis caused by these iatrogenic effects. The composition of the oral and fecal microbiota on patient samples will be analyzed in relation to disease outcome, such as infections, length of stay and number of comorbidities. The goal is to design clinical interventions, where infections and antibiotics use can be minimized, using strategies such as selective digestive tract decontamination (SDD) or enforcement of the normal microbiota by clinical nutrition with pre- and probiotics. Specific requirements: background in (medical) biology or microbiology; experience with molecular biology, bioinformatics and biostatistics is beneficial.

ESR 3.3 The role of oxidative stress in mucositis of oncological patients: can supportive care with prebiotics and vitamins aimed at the microbiome reduce and prevent infections

Mucositis is an inflammatory condition of the gastric tract in oncological patients that is induced by chemotherapy and makes patients vulnerable to malnutrition and infections. The microbiota in the gastric tract plays an essential role in this and recent studies show that the anaerobic microbiota is strongly reduced during mucositis. The project is to study in an established rat model, if mucositis can be ameliorated and infection can be reduced by supportive care with prebiotics and vitamins. The level of oxidative stress during chemotherapy will be related to animal health parameters and microbiota. The PhD student will be involved in nutritional intervention studies with treatment success and infection rates as outcome. Specific requirements: background in (medical) biology or microbiology; willingness to work with animals; experience with molecular biology, bioinformatics and biostatistics, and animal trials is beneficial.

Nr of positions available : 3

For more information:http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34096368

3 PhD positions PRONKJEWAIL – Iatrogenic influence on the microbiome

Organisation:  University Medical Center Groningen (The Netherlands)
Application deadline:  30/09/2016

Microbes in Health and Disease program at the UMCG, the Netherlands offers 16 PhD positions within the project PRONKJEWAIL (H2020/MSCA COFUND). Research training builds on 4 Pillars: 1) Vaccines and primary prevention, 2) Personalized detection and infection prevention, 3) Iatrogenic influence on the microbiome, 4) Personalized therapy/stewardship.

Applicants must hold a master’s degree or equivalent, be in the first 4 years of their career and not yet have been awarded a doctoral degree. Applicants must not have been resident at the Netherlands for more than 12 months in the past 3 years.
Please email your application to pronkjewail@umcg.nl . The application must be a single pdf file including motivation letter, CV, copies of Master’s degree or equivalent, list of grades, English proficiency certificate (TOEFL > 6.5, IELTS > 92 or equivalent) and 2 letters of recommendation. In the subject of the email indicate the selected position. In the file name include YOUR_NAME_ESR_number.
Description
Iatrogenic influence on the microbiome

ESR 3.1 The influence of the presence of antibiotics, chlorine, disinfectants and heavy metals in environmental water streams on the gut microbiome

The goal of this project is to study the influence of the presence of antibiotic, chlorine, disinfectants and heavy metals in environmental water streams on the gut microbiome, possibly leading to an increased presence of antibiotic resistant bacteria (ARB) in the gut. The results will be used to support prevention and improve diagnostics of ARB in patients. The PhD student will analyze the effect of colonization with community-acquired ARB. Specific requirements: background in water research, veterinary research, medical microbiology or molecular biology; knowledge of next generation sequencing and/or bioinformatics is beneficial.

ESR 3.2 The effect of hospitalization and drug use on the composition of the oral and fecal microbiome

Hospitalization and drug use have an effect on the normal functioning of the body and its relationship with microbes. Infectious complications in patients may be associated with a dysbiosis caused by these iatrogenic effects. The composition of the oral and fecal microbiota on patient samples will be analyzed in relation to disease outcome, such as infections, length of stay and number of comorbidities. The goal is to design clinical interventions, where infections and antibiotics use can be minimized, using strategies such as selective digestive tract decontamination (SDD) or enforcement of the normal microbiota by clinical nutrition with pre- and probiotics. Specific requirements: background in (medical) biology or microbiology; experience with molecular biology, bioinformatics and biostatistics is beneficial.

ESR 3.3 The role of oxidative stress in mucositis of oncological patients: can supportive care with prebiotics and vitamins aimed at the microbiome reduce and prevent infections

Mucositis is an inflammatory condition of the gastric tract in oncological patients that is induced by chemotherapy and makes patients vulnerable to malnutrition and infections. The microbiota in the gastric tract plays an essential role in this and recent studies show that the anaerobic microbiota is strongly reduced during mucositis. The project is to study in an established rat model, if mucositis can be ameliorated and infection can be reduced by supportive care with prebiotics and vitamins. The level of oxidative stress during chemotherapy will be related to animal health parameters and microbiota. The PhD student will be involved in nutritional intervention studies with treatment success and infection rates as outcome. Specific requirements: background in (medical) biology or microbiology; willingness to work with animals; experience with molecular biology, bioinformatics and biostatistics, and animal trials is beneficial.

Nr of positions available : 3

For more information:http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34096368

4 PhD positions PRONKJEWAIL: Vaccines and primary prevention

Organisation:  University Medical Center Groningen (Germany)
Application deadline:  30/09/2016
Microbes in Health and Disease program at the UMCG, the Netherlands offers 16 PhD positions within the project PRONKJEWAIL (H2020/MSCA COFUND). Research training builds on 4 Pillars: 1) Vaccines and primary prevention, 2) Personalized detection and infection prevention, 3) Iatrogenic influence on the microbiome, 4) Personalized therapy/stewardship.

Applicants must hold a master’s degree or equivalent, be in the first 4 years of their career and not yet have been awarded a doctoral degree. Applicants must not have been resident at the Netherlands for more than 12 months in the past 3 years.
Please email your application to pronkjewail@umcg.nl. The application must be a single pdf file including motivation letter, CV, copies of Master’s degree or equivalent, list of grades, English proficiency certificate (TOEFL > 6.5, IELTS > 92 or equivalent) and 2 letters of recommendation. In the subject of the email indicate the selected position. In the file name include YOUR_NAME_ESR_number.
Description
ESR 1.1 Role of autophagy protein in the life cycle of mosquito-borne viruses

Autophagy is an intracellular degradative process that is part of our innate immunity and several microbes have developed mechanisms to subvert it. The project will focus on arboviruses including Dengue, West Nile, Zika and Chikungunya. Using our siRNA library and GFP-expressing virus strains, the candidate will identify the autophagy genes relevant for the infections. We expect to characterize new factors involved in the life cycle of these human pathogens, with the ultimate goal of providing novel therapeutic targets for the treatment of their infections. Specific requirements: background in microbiology/virology and/or cell biology is a plus.

ESR 1.2 Outsmarting influenza virus immune escape

Influenza virus infections in immunocompromised individuals are associated with high morbidity and mortality. Due to constant mutation of the virus RNA genome vaccines may fail to induce adequate protection. The focus of this project is on the dynamics of influenza-specific antibody responses after vaccination using a combination of epidemiological methods, assessment of biobank samples and in vitro and in vivo experiments. This approach is expected to render novel leads for optimization of influenza vaccination strategies. Specific requirements: background in immunology, virology and/or epidemiology and research experience; willingness to work with animals.

ESR 1.3 Optimized administration of antimicrobial drugs for prophylaxis in immunocompromised patients

Antimicrobial drugs used for prophylaxis in immunocompromised patients are often prescribed in a one size fits all, which may lead to break through infections or adverse drug effects. Training will address adequate dosing of the 6 most important antimicrobial drugs used for prophylaxis. You will evaluate current practice and develop a dosing algorithm for optimized administration of antimicrobial drugs. The cost effectiveness of different dosing strategies will be calculated. Specific requirements: knowledge of pharmacokinetics and pharmacodynamics and infectious diseases, willingness to learn Dutch.

ESR 1.4 Impact of SDD on post-operative outcome in esophagectomy /Innovative fiber-based molecular fluorescence endoscopy in suspected lung infections

After esophageal surgery, bacterial pulmonary infection is one of the largest determinants of complications. Selective Decontamination of the Digestive tract (SDD) is effective in intensive care patients. The PhD student will set up a multicenter randomised clinical trial of SDD in patients undergoing esophagectomy.
The PhD candidate will introduce innovative optical imaging by microendoscopy and targeted optical tracers in patients with the suspicion of pneumonia for the early detection of bacterial and fungal infections. Specific requirements: medical doctor, experience in clinical studies and innovation is preferable, willingness to learn Dutch.

Nr of positions available : 4

For more information:  http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/34096364